Go to your ">Drive<:\Program Files (x86)\Origin Games\Mass Effect 2\Binaries\Core" folder and delete the "ActivationUI.exe"

Then repair the game. (in Origin > Game Library > right click ME2 > Repair) > test.

If that don't helps, go to your ">Drive<:\Program Files (x86)\Origin Games\Mass Effect 2\Binaries" folder and rename the "MassEffect2.exe" to "MassEffect2Launcher.exe"

Then rename the "ME2Game.exe" to "MassEffect2.exe" > test.

구글검색걸과 찾았습니다 ㅎㅎ